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Mark Pershouse

Associate Professor

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Personal Summary

After completing undergraduate work in biology at Texas Tech University in Lubbock, Dr. Pershouse earned a Ph.D. in Biomedical Sciences under the guidance of Professor Elton Stubblefield at the University of Texas Graduate School of Biomedical Sciences in Houston. Following a postdoctoral fellowship at the M.D. Anderson Cancer Center under the supervision of Professor Peter Steck, and a brief postdoctoral associate position at Baylor College of Medicine with Drs Craig Chinault and Allan Bradley, he joined the faculty at The University of Montana as a Research Assistant Professor in September of 2000, was promoted to Assistant Professor in 2002, and to Associate Professor in 2007.

Field of Study

The Pershouse lab focuses on applying the most current knowledge provided by the human genome sequencing project to understanding fundamental mechanisms of molecular response to environmental toxins.  By studying the response of thousands of genes within a cell population to toxicants such as asbestos, organophosphates, or metals, we can gain new insight into possible mechanisms of response and open new avenues for therapeutic intervention. We can also use the characteristic cohort of genes responding to a stimulus as a form of toxic signature, and can generate a powerful tool for monitoring exposures and finding genes responsible for our individual risk of disease following exposure.

We are applying cDNA microarray technology to the study of asbestos-related lung fibrosis and lung cancer in Libby, Montana. This work involves the development of a suitable mouse model that will replicate many features of the human disease following asbestos exposure.  In parallel, we will be analyzing bronchial alveolar lavage (BAL) samples and peripheral blood from controls and affected Libby residents to validate the findings in the mouse model.

We are also collaborating with other laboratories to perform similar searches for biomarkers and toxic signatures from exposures to heavy metals, organophosphates, and organotins.

Selected Publications

Melisa Bunderson Schelvan, Amy Erbe, Corbin Schwanke, and Mark A. Pershouse. Suppression of the MDM4 gene causes changes in cell cycle control in a human mesothelial cell line responsive to UV exposure. Submitted to Genes, Chromosomes, and Cancer. March 2008.

Melodie L. Weller, Trevor C. Neal, Ida M. Stone, Corbin Schwanke, Mark Pershouse, and David J. Poulsen. Selective over expression of EAAT2 in astrocytes enhances neuroprotection. Submitted to Neuroscience.  September 2007.

Melisa Bunderson Schelvan, Amy Erbe, Corbin Schwanke, and Mark A. Pershouse. Suppression of the MDM4 gene causes changes in cell cycle control in a human mesothelial cell line responsive to UV exposure. Submitted to Molecular Carcinogenesis.  August 2007.

Mark A. Pershouse, Melisa Bunderson Schelvan, Corbin Schwanke  Omics Information Resource, a chapter from Information Resources in Toxicology (4th Edition) Edited by Wexler, Hakkinen, Mohapatra & Stoss, National Library of Medicine. Published by Elsevier. In press 2007.

Mark A Pershouse, Melisa Bunderson Schelvan, Amy Erbe, Corbin Schwanke, Elizabeth Putnam.  Toxicoinformatics Information Resource, a chapter from  Information Resources in Toxicology (4th Edition) Edited by Wexler, Hakkinen, Mohapatra & Stoss, National Library of Medicine. Published by Elsevier. In press 2007.

Larson SJ, Putnam EA, Schwanke CM, and Pershouse MA. (2007) Potential surrogate markers for gamma-hydroxybutyrate administration may extend the detection window from 12 to 48 hours. Journal of Analytical Toxicology. 31:15-22.

Mark A. Pershouse, Shane Heivly, and Teri Girtsman (2006) The role of SV40 in malignant mesothelioma and other human malignancies. In press Inhalation Toxicology.

Jean C. Pfau, Mark A. Pershouse, and Elizabeth A. Putnam. (2006) "Conference Summary. Directions and Needs in Asbestos Research: New Insights."  In press Inhalation Toxicology.

Jared M Brown, Corbin M Schwanke, Mark A Pershouse, Jean C Pfau, and Andrij HolianEffects of Rottlerin on Silica-Exacerbated Systemic Autoimmune Disease in New Zealand Mixed Mice. Am J Physiol Lung Cell Mol Physiol. in press (July 22, 2005).

Brown, JM, Pfau, JC, Pershouse, MA, and Holian, A. Silica, apoptosis, and autoimmunity. In press Journal of Immunotoxicology 1(3,4):177-187, 2004.

Kruzelock RP, Cuevas BD, Wiener JR, Xu FJ, Yu Y, Pershouse M, Lovell MM, Killary AM, Mills GB, and Bast RC.  "Functional evidence for an ovarian cancer tumor suppressor gene on chromosome 22 by microcell-mediated chromosome transfer."  Oncogene. 19(55) 6277-6285: 2000.

Pershouse MA*, Li J*, Brundage E, Di Wm, Bradley A, and Chinault, AC. (first authors equal) "A 3 cM BAC Contig from Mouse Chromosome 11 surrounding BRCA1 in the Human 17 Syntenic Region."  Genomics. 69(1): 139-142. 2000.

Steck PA, Lin H, Langford LA, Jasser SA, Koul D, Yung WK, and Pershouse, MA. "Functional and molecular analyses of 10q deletions in human gliomas."  Genes Chromosomes Cancer. 24(2):135-43. 1999.

Lin H, Bondy ML, Langford LA, Hess KR, Delclos GL, Wu X, Chan W, Pershouse, MA, Yung WK, and Steck, PA. "Allelic deletion analyses of MMAC/PTEN and DMBT1 loci in gliomas: relationship to prognostic significance."  Clinical Cancer Research. 4(10):2447-54. 1998.

Hadi AH, Pershouse MA, Jasser S, Hong YK, Yung WKA, and Steck PA. "Differentially expressed gene products in glioblastoma cells suppressed for tumorigenicity."  Journal of NeuroVirology. 4: 217-226. 1998.

Teng DH-F, Hu R, Lin H, Davis T, Iliev D, Frye C, Swedlund B, Hansen B, Vinson VL, Gumpper LE, Ellis L, El-Naggar A, Frazier M, Jasser S, Langford L, Lee J, Mills GB, Pershouse MA, Pollack RE, Tornos C, Troncoso P, Yung WKA, Fujii G, Berson A, Bookstein R, Bolen JB, Tavtigian ST, and Steck PA: "MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines."  Cancer Research. 57: 5221-5225. 1997.

Pershouse M, Stubblefield E, Hadi A, Pereira-Smith O, Yung WKA, and Steck P: "Suppression of transformation and tumorigenicity after transfer of chromosome 4 into a human glioblastoma multiforme cell line."  Genes, Chromosomes, and Cancer. 20:260-267. 1997.

Steck PA, Pershouse MA, Jasser SA, Yung WKA, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R, Swedlun, B, Teng DHF, and Tavtigian SV.  "Identification of a candidate tumor suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers."   Nature Genetics. 15: 356-362. 1997.

Hadi Ligon A, Pershouse MA, Jasser SA, Yung WKA, and Steck PA: "Identification of a novel gene product ,RIG, that is down-regulated in human glioblastoma."  Oncogene. 14:1075-1081. 1997.

Pershouse MA, el Naggar A, Hurr K, Yung WKA, and Steck P: "Deletion mapping of chromosome 4 in head and neck squamous cell carcinoma."  Oncogene. 14:369-373. 1997.

Akeyson EW, McCutcheon IE, Pershouse M, Steck PA, and Fuller GN: "Primitive neuroectodermal tumor of the median nerve. Case report with cytogenetic analysis."  Journal of Neurosurgery. 85:163-169. 1996.