People
Personal Summary
Dr. Smith completed a B.S. degree in Pharmacy from the University of Georgia in Athens, GA (1967) and a Ph.D. in Pharmacology (1977) from the University of Mississippi in Oxford. After graduate school he accepted a position at The University of Montana and has been here since 1977.
Field of Study
Work in my lab focuses on:
- Myocardial Preconditioning and Ischemia-Reperfusion Injury
- Diabetic Modification of Cardiovascular Function
- Drug Metabolism & Cytochrome P-450 Isozymes
- Interactions of Soluble Fibers and Cardioactive Drugs
- Perfluorohydrocarbons and Their Impact on Oxygen Deprivation
- Energetics of CNS Cells Exposed to Potential Neurotoxins
Selected Publications
Smith, JR, Botchek, S, Manson, R, and Jaksha, J: In Vitro interactions of selected soluble fibers with the cardiovascular drugs, nicotinic acid (Niacin) and pentoxifylline. Proc. Western Pharmacology Society, 35:107-111, 1992.
Zhao, L, Smith JR, and Eyer, CL: Effects of a 100% perfluorooctylbromide emulsion on ischemia/reperfusion injury following cardioplegia. Biomat., Art. Cells, & Immob. Biotech. 23(4):513-517, 1995.
Tarr, BD, Fraser, BH, and Smith, JR: Aminoguanidine prevents the negative inotropy associated with rabbits on high-fat, high-cholesterol diets. Pharmaceutical Sciences 2:1-4,1996.
Elliott, GT, Comerford, ML, Smith, JR, and Zhao, L: Myocardial ischemia/reperfusion protection using MPL-A is abrogated by the ATP-sensitive potassium channel blocker, glibenclamide. Cardiovascular Research 32:1071-1080, 1996.
Zhao, L, Weber, PA, Smith, JR, Comerford, ML and Elliot ,GT: Role of inducible nitric oxide synthase in pharmacologic "preconditioning" with monophosphoryl lipid A. J. Molec. Cell. Cardiology 29:1567-1576, 1997.