Cancer

Cancer research projects by BMED faculty include investigations on breast cancer pharmacogenomics, glial brain tumors, mesothelioma, natural products, tumor-activated drugs, and tumor-selective imaging agents.

The interests in cancer research among BMED faculty cut across many disciplines including: pharmacology, toxicology, immunology, neuroscience, medicinal chemistry, genetics and pharmacogenomics. Departmental faculty utilize state-of-the-art approaches and technologies in synthetic organic chemistry, molecular biology, molecular pharmacology, genetics, imaging, spectroscopy, and computational modeling in their research. Ongoing projects range from pharmacogenomics of drug-metabolizing enzymes to molecular genetics of cancer, gene-environment interactions in cancer development, isolation of bioactive metabolites from bacteria and fungi, immune response and modulation in cancer, and biomarker and anticancer drug discovery. A list of BMED faculty interests in cancer can be found below.

Students working in the Cancer labs have pursued their graduate degrees in:

Participating Faculty

Howard D. Beall

Professor & Associate Dean

Discovery of novel, targeted anticancer agents and their mechanisms of action.

Richard Bridges

Regents Professor

Exploiting the presence of glutamate transporters present on select tumor types, such as glioblastoma, as potential targets for novel therapeutics and imaging agents.

Yoonhee Cho

Assistant Professor

Development of epigenetic biomarkers for diagnosis/prognosis of breast cancer

Nicholas R. Natale

Professor of Medicinal Chemistry

Mark Pershouse

Associate Professor

Liz Putnam

Chair, Professor

Gene-environment interactions in the development of cancer after asbestos exposure in mouse models and humans.

Andrea Stierle

Research Professor

Isolation, characterization and development of microbial metabolites with pharmaceutical potential regulate inflammation, cell migration, and apoptotic pathways associated with onset and progression of cancer.

Donald Stierle

Research Professor

Isolation and characterization of microbial metabolites with potential to regulate inflammatory and apoptotic pathways associated with onset and progression of cancer 

Erica Woodahl

Associate Professor